Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide.
نویسندگان
چکیده
Mice were treated with ketoconazole with and without dimethyl sulfoxide. Concentrations of ketoconazole at 3 and 5 h after treatment were significantly higher in serum (P less than 0.05) and brain tissue homogenate (P less than 0.01) of mice treated with dimethyl sulfoxide than in those of mice not treated with dimethyl sulfoxide.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 30 4 شماره
صفحات -
تاریخ انتشار 1986